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Olesen, U

Rushing through the titration schedule often means more severe GI symptoms, worse adherence, and sometimes temporary discontinuation, which ultimately slows progress

However, individual responses may differ based on factors such as initial weight, adherence to the treatment plan, diet, exercise, and other lifestyle factors

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Appetite 82 , 8590 (2014)

But the mechanism isnt just more appetite suppression . Theres evidence that GIP signaling may help shift how nutrients are partitioned, potentially favoring fat energy utilization during the fasted state, and possibly mitigating some of the lean mass loss seen with GLP-1 monotherapy